진학프로석·박사 채용 접수 플랫폼

The main objective of RACE-PRIME is to transform the IIMCB into a world-class center of excellence in RNA and cell biology. Researchers would like to use the results of core research to develop therapies and diagnostic methods, discover new therapeutic objectives, and identify molecules with desirable properties so that they can be developed into medications.

Project description:

Upon gaining access to a suitable host cell, viruses will hijack the cell's protein synthesis machinery and use it to assemble new viral proteins. One common strategy involves the use of an internal ribosome entry site (IRES), which directly recruits host ribosomes to the viral RNA, bypassing conventional cap-dependent translation initiation. In order to function effectively, IRESs require the assistance of various cellular RNA-binding proteins. These accessory factors, termed ITAFs (IRES trans-acting factors), help the IRES fold into its final, active conformation. One particularly important ITAF is the RNA-binding protein PTBP1, which is required by a diverse range of pathogenic viruses. In this project, you will systematically identify human viruses which require PTBP1 for efficient viral translation. In parallel, you will evaluate the antiviral efficacy of a recently-developed small molecule inhibitor of PTBP1. 

For more information about our laboratory and research, please visit our lab website.

Requirements for the candidate:

1. Possesses a Ph.D. in biological sciences or related field obtained within the past 5 years; however, the 5-year period is calculated from the year of obtaining the Ph.D., or plans to defend his/her dissertation prior to the start of employment (planned date is 01.06.2025 or later).
2. Has solid knowledge and documented laboratory experience in RNA biology.
3. Experience with ribosome profiling, bioinformatics, human tissue culture, and/or virology methods will be a plus.
4. Has excellent interpersonal skills, initiative, and ability to work independently and in a high-performance team.
5. Has the ability to draft (in English) scientific papers for academic journals.
6. Has the ability to communicate (in English) complex information clearly, orally and in writing.
7. Has good presentation skills (ideally having presented during at least one international conference).
8. At least one publication in an international peer-reviewed journal.