진학프로석·박사 채용 접수 플랫폼

The role

PrecisionTox is a European-funded project, the overarching aim of which is to establish a new, 3Rs- compliant (Replacement, Reduction, Refinement), cost-effective testing paradigm for chemical safety assessment — Precision Toxicology — that revolutionises regulatory toxicology, replaces animal testing, reduces uncertainty, and determines safety factors in assessing risks to human health. This goal will be accomplished by identifying molecular key event (KE) biomarkers, predictive of chemically induced adverse health effects in humans, that feed directly into regulatory and industry practice via the systematic use of distantly related animal species from across the tree of life and the highly interdisciplinary mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law.

Within this project, our group at the CRG focuses on the analysis of bulk and single cell RNA-seq from five different model species (Danio, Xenopus, Caenorhabditis, Daphnia and Drosophila), human cell lines and organoids after treatment with selected putative cardio, neuro, and hepatotoxic compounds emerging from other efforts within PrecisionTox. Our aim is to employ existing and develop novel computational approaches to assess the impact of the chemical compounds on gene expression or co-expression networks across the model species and explore their predictive potential for human toxicity assessment. This project fits overall within a larger overarching goal in our group of developing methods to relate genome to phenome across the tree of life.

We are searching for a talented post-doctoral researcher with a strong computational background to join the group. The postdoctoral researcher will be responsible for the integration of the transcriptomic data and the other datasets generated during the project as well as for the implementation of models to predict toxicity in humans based on the common features observed in the different organisms upon compound exposure.

About Guigo’s lab

The overarching theme of the research in our lab is the understanding of the information encoded in genomic sequences, and how this information is processed in the pathway leading from DNA to protein sequences. More specifically, we are interested in the epigenetic regulation of gene expression and RNA processing, the relationship between molecular phenotypes and higher order endophenotypes and organismal phenotypes, and the identification of functional regions on the genome of all living beings. Our group is mostly computational, and we do both large-scale data analysis and development of methods, but it has also an important experimental component. We participate in many large scale international functional genomics projects, such as ENCODE, GTEx, BluePrint and others.