Institute of Physical Chemistry Polish Academy of Sciences

Post-doc

Post-doctoral position - Recruitment No 20/2025

마감2025.06.13~2025.07.18

채용 정보

  • 접수 기간

    2025.06.13 00:00~2025.07.18 12:00

  • 접수 방법

    이메일지원더보기

  • 채용 구분

    경력

  • 고용 형태

    계약직

  • 지원 자격

    박사

  • 모집 전공

    화학, 화학공학, 물리・과학더보기

  • 기관 유형

    연구기관

  • 근무 지역

    해외(폴란드)더보기

Post-doc position available in the Institute of Physical Chemistry PAS within National Science Center (NSC) OPUS 27


Project no 2024/53/B/ST4/01213


Entitled “Effect of lipid nanoparticles on the nanostructure of cell cytoplasm”


Leader Dr inż. Karina Kwapiszewska


Lipid nanoparticles (LNPs) are crucial for delivering nucleic acids into cells, poweriang mRNA vaccines and gene editing. While generally considered low-toxic (>24h), we observed significant intracellular nanostructure remodeling and diffusion hindrance within 4 hours of LNP exposure. Using Fluorescence Correlation Spectroscopy (FCS), we found these disturbances far exceed those from other stressors. We hypothesize that LNP lipids interact with cell membranes, causing this remodeling, potentially impacting organelle health and cellular stress. This project will use a soft matter approach and high-throughput biochemical assays, to analyze LNP-cell interactions and their biological consequences. We aim to understand the physicochemical impact of LNPs on cell membranes (1-100nm scale) and connect these findings to standard toxicity measures. This research will reveal potential adverse LNP effects, crucial for both molecular biology and clinical applications.

근무 예정지

대표해외(폴란드) : Poland, Institute of Physical Chemistry Polish Academy of Sciences, Warsaw, 01-224, Kasprzaka 44/52

관련 키워드

ChemistryPhysical chemistryPhysicsBiophysics

기관 정보

Institute of Physical Chemistry Polish Academy of Sciences

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  • 기관유형

    연구기관

  • 대표전화

    +48 22 343 31 08

  • 대표주소

    Marcina Kasprzaka 44/52, 01-224 Warszawa

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