진학프로석·박사 채용 접수 플랫폼

The integrity of the mitochondrial network is maintained by the selective removal of damaged mitochondria through mitophagy [1]. This process is essential for proper mitochondrial function, and dysfunction in mitophagy can lead to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's [1].

However, mitophagy can also trigger cell death in cancer cells, for example, via ferroptosis [2]. Our lab aims to leverage this mitophagy-related mechanism to induce cell death in liver cancer cells. To achieve this, we are developing small molecule drugs that enhance mitophagy. We have already demonstrated that a prototypic compound effectively kills liver cancer cells, and we are now seeking a creative and goal-oriented PhD student to decipher its mechanism of action.

If you are interested and eager to learn more, please send your resume to Prof. Einav Gross at einavg@ekmd.huji.ac.il and join a team at the forefront of biological and medical sciences.

We offer full scholarships to suitable PhD candidates. While experience in tissue culture and microscopy is beneficial, it is not required. However, experience in molecular biology techniques (cloning and PCR) is essential.

Candidates will be considered on a rolling basis until the positions are filled.

The Hebrew University of Jerusalem (HUJI) ranks within the world’s top 100 universities and attracts roughly 2,000 international students each year, representing about 90 nations. Most enroll through the Rothberg International School, which, along with HUJI’s other faculties, offers numerous English-language undergraduate and graduate programs. The university actively tailors its facilities and support services to meet the academic and personal needs of its global student community.

1. Srivastava V, Gross E: Mitophagy-promoting agents and their ability to promote healthy-aging. Biochemical Society Transactions 2023, 51(5):1811-1846 doi:10.1042/BST20221363.

2. Yang M, Wei X, Yi X, Jiang DS: Mitophagy-related regulated cell death: molecular mechanisms and disease implications. Cell Death Dis 2024, 15(7):505 doi:10.1038/s41419-024-06804-5.PubMed Central PMCID: PMCPMC11252137.