진학프로석·박사 채용 접수 플랫폼

- work environment: We are looking for a Post-Doc who wants to contribute to the allow successful delivery of APIs or key intermediates, by the use of novel technologies such as continuous flow mechanochemistry by reactive twin screw extrusion, identified by IUPAC as one of the ten top emerging technologies that will change the world. A unique opportunity for you to work in a scientific area of great importance, innovative and disruptive, in a setting at the interface with the industrial needs and in close interactions with excellent academic groups members of the European Programme Horizon IMPACTIVE (Innovative Mechanochemical Processes to synthesize ACTIVE pharmaceutical ingredients).

- main mission: The Post doc will work under the responsibility of Dr. Evelina Colacino, on the development of sustainable methodologies for organic synthesis, with a special attention to the preparation of value-added compounds for the pharmaceutical industry in large-scale by continuous flow mechanochemistry, mainly based on reactive twin screw extrusion and possibly by resonant acoustic mixing.

- activities: As a Post-Doc, you will deal with the synthesis and development of APIs or key intermediates, and their characterization (including at the solid state). Your main research objectives will be to propose and design straightforward access (meaning specifically route scouting) to APIs by reactive twin screw extrusion mainly (i.e. continuous flow mechanochemistry) and by resonant acoustic mixing possibly, at different scale, in alternative to solution-based procedures and to improve the ecological footprint of each synthesis at laboratory and large scales. The daily synthesis work will be performed at the Université de Montpellier (Charles Gerhardt Institute of Montpellier, ICGM) in France.

The research activity will mainly focus on:

•Design of scalable and green routes for APIs or key intermediates by reactive twin screw extrusion in alternative to solution-based processes currently used in the industry. Imp,eentation of the process by resonant acoustic mixing could be considered, depending on the project needs.

•Investigation of the mechanochemical process parameters to access them at different scales;

•Green Chemistry metrics applied to the processes developed within the project ;

•Solid state characterization of each APIs or key intermediates;

•Process development to access new pharmaceutical forms

The net monthly salary is between €2,200 and €2,270

The contract duration is 7 months

Skills/Qualifications

To qualify for the position of Post-Doc, you must have a doctoral degree in a relevant field such as medicinal chemistry, preparative organic chemistry, with solid skills in synthesis and analytical methods (NMR, HPLC, MS, IR, etc.). Candidate should have a strong interest in the technological aspects of the project. Experience in green chemistry, mechanochemistry, reactive extrusion and solid state characterization is considered meritorious for this position, but not compulsory.

We are looking for you who can work independently but also in close collaboration with the group members and as a part of the European Programme Horizon IMPACTIVE. You can plan and organize your own work, take your own initiatives and responsibility, be analytical and creative and be able to deliver results in time. You also need to be able to report to the founders, hence, need good communication skills and an interest for multidisciplinary research.