진학프로석·박사 채용 접수 플랫폼

As part of the CILIAS Project, the Postdoctoral Researcher will be responsible for investigating the mechanisms underlying retinal degeneration in the context of ciliopathies, with a particular focus on Alström syndrome, using both in vivo models (particularly murine models) and in vitro systems (fibroblasts, iPSCs, retinal organoids, and RPE).

Responsibilities:

• • Establishment and colony management, including operational aspects related to the production and analysis of the ALMS mouse lines selected by the consortium.
• • Close collaboration with the Research Engineer (AI) of UMRS_1112 at CRBS, who will be partially assigned to the project.
• • Organization and implementation of experimental work involving mouse models: functional analyses (including ERG and OCT), development of additional functional assays, locally conducted histological analyses, and preparation of samples for collaboration with the Lyon-based team, including quality control of transferred materials and follow-up of results for interpretation.
• • Analysis of fibroblasts, iPSCs, retinal organoids, and RPE models already generated by the laboratory, as well as the development of new models depending on the variants under investigation.
• • Acting as a regular point of contact within the collaboration with the Lyon-based team.
• • Contribution to data analysis and preparation of manuscripts within the framework of the ANR project and related projects on retinal ciliopathies.

Required Skills and Qualifications:

• • Certification/authorization for animal experimentation (mouse models), with demonstrated autonomy in colony supervision (breeding and experimental management), data analysis, and synthesis of results, with a strong focus on retinal analysis; ability to collaborate effectively with the Research Engineer.
• • Solid expertise in cellular and molecular biology, including advanced cell culture techniques (notably iPSCs and organoids).
• • Foundational expertise in retinal histology, including experience relevant to ciliopathies and familiarity with approaches developed by the Lyon team (U-ExM).