진학프로석·박사 채용 접수 플랫폼

Context

Glial tumors are the most common primary brain tumors, with an incidence of approx. 50,000 to 100,000 per year. Patients for grade II diffuse gliomas are usually treated with an awake surgery to maximize the tumor resection while preserving neurological functions. However, it rarely allows complete removal of the tumor lesion which often infiltrates deep brain regions. Therefore, setting up a long-term follow-up by MRI is really required. The objective of project STRATUM, funded
by the French Institute for Health and Medical Research (INSERM), is to develop and validate an utrasound (US) imaging tool complementary to MRI perfusion for monitoring and diagnosing neo-angiogenesis of brain tumors to improve early diagnosis of lesion progression and to better adapt oncological treatments. The project brings together 3 research labs:

• • the Institute of Electronics, Microelectronics and Nanotechnologies (IEMN)Villeneuve d’Ascq, France.
• • the IBrain group, INSERM, Tours University Hospital, Tours, France.
• • the Institute of Research in Computer Science, Paul Sabatier University, Toulouse,France.

We have proposed to adopt a very recent concept of 3D Ultrasound Localization Microscopy (ULM) imaging for in-vivo brain tumors without skull opening. At
IEMN, our specific task is to compensate for phase aberration due to through-skull transmission, that leads to shadow zones and innacuracy in localizing microbubles. For that purpose, we have developed a phase-aberration correction approach based on a patient-specific numerical model of the skull.

Missions

The research associate will have to test the efficiency of this aberration correction approach on both numerical and real phantoms of skull and brain, and possibly to propose alternative approaches. In addition, he/she will develop an ultrasonic technique to estimate the patient-specific local thickness and velocity of the skull, which are required to compensate for phase aberration. Finally, he/she will be involved in experiments on ultrasound phantoms and clinical tests of the whole imaging methodology on patients during brain surgery at Tours University Hospital.

Additional information:

• • Salary: Approx. 2700 €
• • Duration : 12 months, starting from September 2026
• • Contacts:[email protected]@centralelille.fr