진학프로석·박사 채용 접수 플랫폼

Location: Institute of functional genomics (IGF), Montpellier, France
Position Type: Full-time, Postdoctoral Researcher
Duration: 18 months renewable

Start Date: 1st of June 2025
We are seeking an enthusiastic and motivated Postdoctoral Researcher to join the Granier-Mouillac team at IGF (University of Montpellier, CNRS, INSERM) to investigate G-Protein Coupled Receptors (GPCRs) function using cutting-edge visual proteomics techniques, with a specific focus on cryo-Electron Tomography (cryo-ET). This is an exciting opportunity to contribute to groundbreaking research at the intersection of structural biology, pharmacology, and advanced imaging technologies.

Key Responsibilities:

• Design and conduct experiments using cryo-ET to visualize GPCRs signaling complexes in their native membrane environment.
• Investigate GPCRs' signaling mechanisms with high-resolution imaging techniques.

• Use state-of-the art approach (cryo-CLEM, cryo-FIB-SEM, cryo-TEM) to prepare suitable

  lamellae for cryo-ET.

• Apply visual proteomics to explore the protein-protein interactions and gain functional insights

  into GPCRs function.

• Collaborate with interdisciplinary teams of scientists and engineers to develop and optimize

  imaging protocols.

• Analyze large datasets generated from cryo-ET and related techniques, using state-of-the-art

  software and computational tools.

• Publish findings in high-profile scientific journals and present research at national and

  international conferences.

  Qualifications:

• A Ph.D. in Structural Biology, Biophysics, Cell Biology, or a related field.

• Strong background in cryo-ET, cryo-EM, or other electron microscopy-based imaging

  techniques.

• Experience in visual proteomics, including protein isolation, mass spectrometry, and

  bioinformatics, is highly desirable.

• Experience in EM data treatment (cryoSPARC, Relion, Amira, Dragonfly).
• Knowledge of GPCRs, their structural biology, and signaling pathways is an advantage.
• Strong problem-solving skills, ability to work independently and as part of a collaborative team.
• Excellent communication skills, both written and oral.

• Demonstrated ability to publish in peer-reviewed journals and present scientific findings

  effectively.

  Benefits:

• Opportunity to work with world-class researchers and advanced cryo-imaging technologies.
• Access to state-of-the-art facilities and resources for structural biology research.
• Competitive salary and benefits package.

• Professional development opportunities, including training in new methodologies and

  techniques.

• A dynamic and supportive research environment.

  Application Instructions:

  Interested candidates should submit the following:

1. A cover letter detailing research experience, motivation, and career goals.
2. A CV including a list of publications.
3. Contact information for at least two references.

Please submit your application to sebastien.granier@inserm.fr and aurelien.fouillen@inserm.fr by 15th of april 2025.
The IGF (University of Montpellier/CNRS/INSERM) is committed to diversity and inclusion in its workforce and encourages individuals from all backgrounds to apply.