Institute of Physical Chemistry Polish Academy of Sciences

Post-doc

Post-doctoral position

접수중2025.04.08~2025.05.05 공유하기

채용 정보

접수 기간
2025.04.08 00:00~2025.05.05 12:00
접수 방법
이메일지원더보기
채용 구분
경력
고용 형태
계약직

지원 자격
박사
모집 전공
화학, 화학공학, 물리・과학더보기
기관 유형
연구기관
근무 지역
해외(폴란드)더보기

Post-doc position available in the Institute of Physical Chemistry PAS within National Science Center (NSC) OPUS 27 Project no 2024/53/B/ST4/01213 Entitled “Effect of lipid nanoparticles on the nanostructure of cell cytoplasm” Leader Dr inż. Karina Kwapiszewska Lipid nanoparticles (LNPs) are crucial for delivering nucleic acids into cells, powering mRNA vaccines and gene editing. While generally considered low-toxic (>24h), we observed significant intracellular nanostructure remodeling and diffusion hindrance within 4 hours of LNP exposure.

Using Fluorescence Correlation Spectroscopy (FCS), we found these disturbances far exceed those from other stressors. We hypothesize that LNP lipids interact with cell membranes, causing this remodeling, potentially impacting organelle health and cellular stress. This project will use a soft matter approach and highthroughput biochemical assays, to analyze LNP-cell interactions and their biological consequences. We aim to understand the physicochemical impact of LNPs on cell membranes (1-100nm scale) and connect these findings to standard toxicity measures. This research will reveal potential adverse LNP effects, crucial for both molecular biology and clinical applications.