진학프로석·박사 채용 접수 플랫폼

FIELD: Organic Mechanochemistry applied to the green manufacturing of Active Pharmaceutical Ingredients (APIs). The IMPACTIVE project is funded under Horizon Europe (HaDEA) – Health.

WORK ENVIRONMENT The research activity will be developped at the Institut Charles Gerhardt de Montpellier (ICGM, www.icgm.fr). The hired post-doc will work under the responsibility of Dr. Evelina Colacino.

MAIN MISSIONS. We are looking for a Post-Doc who wants to contribute to the allow successful delivery of APIs or key intermediates, by the use of novel technologies such as mechanochemistry, identified by IUPAC as one of the ten top emerging technologies that will change the world. A unique opportunity for you to work in a scientific area of great importance, innovative and disruptive, in a setting at the interface with the industrial needs and in close interactions with excellent academic groups members of the European Programme Horizon IMPACTIVE (Innovative Mechanochemical Processes to synthesize ACTIVE pharmaceutical ingredients).

ACTIVITIES: The scientific activity will focus on the development of sustainable methodologies for organic synthesis, with a special attention to the preparation of value-added compounds for the pharmaceutical industry, from laboratory to large-scale in batch, by mechanochemistry.

As a Post-Doc, you will deal with the synthesis and development of APIs or key intermediates, and their characterization (including at the solid state). Your main research objectives will be to propose and design straightforward access (meaning specifically route scouting) to APIs by mechanochemistry, in alternative to solution-based procedures and to improve the ecological footprint of each synthesis at laboratory and large scales. The daily synthesis work will be performed at the Université de Montpellier (Charles Gerhardt Institute of Montpellier, ICGM) in France.

The research activity will mainly focus on:

- Design of scalable and green routes for APIs or key intermediates under ball milling in batch in alternative to solution-based processes currently used in the industry;

- Investigation of the mechanochemical process parameters to access them in batch at different scales, and by ‘parallel mechanochemistry’ at laboratory scale;

- Green Chemistry metrics applied to the processes developed within the project ;

- Solid state characterization of each APIs or key intermediates;

- Process development to access new pharmaceutical forms.