진학프로석·박사 채용 접수 플랫폼

The University of Caen Normandy is recruiting for the laboratory Physiopathologie et Imagerie des Troubles Neurologiques (PhIND) A POSTDOCTORAL RESEARCHER IN BIOLOGY.
UNICAEN, with its 29,000 students, is a major actor and driver of higher education and research develop-ment in Normandy. UNICAEN is a member of Normandie Université.

Statutory framework of the position
Category: A
Corps / Grade: IGR BAP A

Workplace
Physiopathologie et Imagerie des Troubles Neurologiques (PhIND)
GIP CYCERON
INSERM UMR-S 1237
Campus Jules Horowitz
Boulevard Henri Becquerel
14000 CAEN – France

Main missions
The mission will be carried out within the project “Targeting tertiary lymphoid structures using magneto-margination” (MAGMA), funded by the European Union’s Horizon Europe Research and Innovation Pro-gram (ERC Consolidator Grant, 2025–2030). The project aims to develop new non-invasive mapping ap-proaches for tertiary lymphoid structures (TLS) using clinically available imaging modalities (MRI) and emerging technologies (MPI), and to identify therapeutic strategies targeting TLS when their presence is as-sociated with poor prognosis.

The project is led by the Physiopathology and Imaging of Neurological Disorders laboratory (PhIND, IN-SERM UMR-S 1237; http://www.phind.fr/index.php/en/).

Non-invasive imaging of inflammation is one of the core research areas of the PhIND laboratory, which is developing an original approach based on the use of large iron oxide particles coupled to monoclonal an-tibodies. The scientific and technological advances generated by the MAGMA project have potential clinical applications, including the diagnosis of chronic inflammation, identification of patients likely to benefit from specific anticancer treatments, and selective modulation of immune responses in autoimmune dis-eases. This integrated diagnostic and therapeutic approach aims to improve detection of chronic inflamma-tion and prevent progression of certain autoimmune diseases.

The postdoctoral researcher will need to rapidly learn the submicrometric particle synthesis techniques al-ready established in the laboratory, then contribute to their optimization and further development. These particles will subsequently be used in experimental models of clinically relevant diseases, in order to demonstrate the feasibility of TLS imaging. The candidate must therefore master MRI, IPM, and magnetic hyperthermia techniques, as well as be capable of implementing experimental models of cancer and auto-immune diseases.

Hierarchical positioning

The recruited researcher will be based in the “tPA and neurovascular pathologies” team of the INSERM UMR-S 1237 PhIND unit, under the supervision of the team leader.

Activities and tasks

- Execution of experimental protocols
• Synthesis and development of contrast agents: Design and carry out synthesis of contrast agents, perform in vitro evaluation, and apply them in experimental models. Anticipate translational potential toward clinical applications.
• Implementation of cancer and autoimmune disease models in a cohort of animals.
• Ensure animal welfare before, during and after procedures.
• Perform imaging protocols (MRI, IPM) and intravenous injections.
• Longitudinal monitoring of animals to assess biocompatibility and degradability of the developed contrast agents.
• Collection of biological samples and associated histological analyses.

- Data analysis: Processing of the collected data, application of statistical methods, interpretation of results, and formula-tion of conclusions based on thorough analysis.

- Active participation within the research team: Contribute to the organization, scientific activities, and development of the team, in interaction with re-searchers, engineers, PhD candidates, and Master’s students.

- Scientific communication and dissemination: Disseminate and promote research results and related intellectual property through publications, presen-tations at international conferences, patents, and industrial partnerships. Establish, participate in, and co-ordinate national and international research collaborations.

Contract
Fixed-term contract (CDD) as a researcher for 24 months, full-time.
Start date: January 2026.