진학프로석·박사 채용 접수 플랫폼

Company Description
The Laboratory of Prokaryotic Gene Regulation at the International Institute of Molecular and Cell Biology (IIMCB), Warsaw, led by Dr. Ewelina Małecka.

Job Description
• Position: Postdoctoral Researcher  
• You will join the project entitled “RNA biology at the phage–bacteria interface” carried out as the OPUS grant (2025/57/B/NZ1/03589) of the National Science Centre, Poland led by Dr. Ewelina Małecka.

About the Project
• Antibiotic resistance in pathogens such as Acinetobacter baumannii is a critical global health challenge.  Bacteriophages offer promising solutions, but whole-phage therapy carries risks of spreading resistance genes.  The project aims to mine phage genomes for molecular effectors that disrupt bacterial physiology.  

• We hypothesize that phages encode novel RNA-binding proteins (RBPs) that hijack host RNA metabolism.  Using time-resolved transcriptomics, interactome mapping, and single-molecule biophysics, the project will dissect the molecular arms race between phages and A. baumannii.  
Techniques include RNA-Seq, CRAC, RIL-Seq, and smTIRF microscopy to uncover mechanisms of RNA regulation and identify targets for next-generation antimicrobials.

Where to Apply
Website: https://system.erecruiter.pl/FormTemplates/RecruitmentForm.aspx?WebID=0b41757b5c40461f9d18dbfefb7653a2

Skills / Qualifications
KEY RESPONSIBILITIES:
• Design and execute experiments in molecular biology, biochemistry, and single-molecule imaging.  
• Perform RNA-Seq and bioinformatic analysis of phage-infected bacterial transcriptomes.  
• Map RNA-protein and RNA-RNA interaction networks using CRAC, RIL-Seq, and co-IP/MS.  
• Reconstitute key interactions in vitro and analyze them using smTIRF microscopy.  
• Collaborate with international partners and mentor junior researchers.  
• Present results at international conferences and contribute to high-impact publications.  
• Initiate and drive new subprojects.

Specific Requirements
CANDIDATE PROFILE  
We are looking for a researcher who:
• Holds (or is about to obtain) a PhD in molecular biology, biochemistry, or biophysics.  
• Fulfills the formal criteria outlined in paragraph 2, point 2.1.1 of the NCN regulations https://www.ncn.gov.pl/sites/default/files/pliki/uchwaly-rady/2024/uchwala84_2024-zal1_ang.pdf  
• Has strong expertise in RNA biology, protein biochemistry, or phage biology; experience with single-molecule techniques is a plus.  
• Is curious about RNA regulation and antimicrobial strategies.  
• Has a solid publication record and can work independently.  
• Communicates fluently in English (written and oral).  
• Is enthusiastic about working in an interdisciplinary, international, and collaborative environment.