진학프로석·박사 채용 접수 플랫폼

The Department of Biological Models focuses on the development and testing of promising polymer conjugates and proteins (therapeutics) suitable for the treatment of tumors, resistance to tumor therapy, and conjugates designed for the treatment of type 2 diabetes.

The successful candidate will conduct independent, conceptually-driven research in the field of novel conjugates that are capable of carrying and releasing growth factors, chemotherapeutics and antibodies. These systems will be tested in vitro in a traditional 2D setting or, newly, in a semi-perfusion 3D system with preformed vasculature and established tissue structure (tumor, Langerhans islet); the so-called “organ on chip”. In these systems, the binding of conjugates to target receptors, the release of growth factors/drugs and the efficacy of treatment in a 3D organ on chip system will be studied in particular. The main projects will include:

• Research on revascularization of Langerhans islets for the treatment of type 2 diabetes
• Development and biological efficacy of antibody-drug-conjugates or antibody-polymer-drug-conjugates in the treatment of cancer (immunotherapy)

using the following experimental methods:

• Determination of cell viability using colorimetric and fluorescent assays
• ELISA
• Flow cytometry
• Fluorescence and confocal microscopy
• General knowledge of working with primary and cancer cell lines is also required.

The position also includes designing experiments, interpreting experimental data, publishing research results in high-impact journals, and active participation in national and international research projects.

More information about the department is available at the web page of the department.