진학프로석·박사 채용 접수 플랫폼

Background information about the project

Quiescence (Q) is a fundamental survival state in eukaryotic cells, allowing organisms to persist under starvation conditions. The project aims to explore the cellular and molecular mechanisms underlying quiescent state variability and its impact on adaptation, antifungal resistance, and population dynamics. The project investigates how individual quiescent cells reorganize their internal structures and how these changes influence population-level survival, stress tolerance, and adaptation. Main questions are: What structural and metabolic changes occur in single quiescent cells over time, and how do they impact survival and regrowth? How do different quiescent phenotypes respond to antifungal treatments, and what are the mechanisms of resistance? How does population density affect quiescence-related survival strategies, and how the Allee Effect influence quiescent cell fitness? What evolutionary trade-offs exist between quiescence depth, regrowth potential, and stress resistance?

About the Position: The Postdoctoral researcher will focus on developing and applying advanced microscopy, microfluidics, and single-cell analysis techniques to investigate quiescence at both individual and population levels.

The sucessfull candidate will:

• Develop and apply fluorescence microscopy and microfluidics techniques for single-cell quiescence analysis.
• Characterize cytoskeletal, mitochondrial, and metabolic changes in quiescent cells.
• Conduct live-cell imaging experiments to monitor quiescent cell aging and reactivation dynamics.
• Investigate antifungal resistance mechanisms in quiescent yeast populations.
• Collaborate with international partners to integrate advanced imaging and microfluidic technologies into the research workflow.
• Contribute to mathematical modelling efforts linking single-cell characteristics to population-level dynamics.
• Prepare scientific publications;
• Participate in conferences.