진학프로석·박사 채용 접수 플랫폼

The team “Post-Transcriptional control of immunity and tumorigenesis” led by Dr. Manuel Diaz-Munoz at the Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY, https://www.infinity.inserm.fr/en/) is seeking an enthusiastic immunologist/biologist to investigate how timely control of mRNA location and translation shapes adaptive immune responses to external antigens and in cancer.

In collaboration with Dr. Vera Pancaldi at the Cancer Research Center of Toulouse (CRCT) (https://www.crct-inserm.fr/en/), and in the context of a project fully funded by the French National Cancer Institute (INCA), we aim to understand how RNA-binding proteins control the subcellular location of mRNAs and the mutagenesis machinery in normal B lymphocytes and in aggressive cancer cells. By analyzing data collected with cutting-edge technologies (trancriptomics, translatomics, RNA:protein and protein:protein interactomics) from human patients, animal models and cancer cell lines, we aim to uncover the impact of such RNA mechanisms in the development of long-term immune protection through vaccination, as well as targeting cancer cell genome stability and cell death.

The applicants are expected to have a strong mixed background in biology analysis in the field of immunology and/or RNA biology. Previous knowledge in fundamental research is needed with proven knowledge in most relevant methodologies in the field. The ideal candidates should be highly motivated, curious, and enthusiastic to work in a highly collaborative team. Proven ability to identify research objectives and meet agreed deadlines, self-motivation, flexibility, and assistance to other ongoing research work is essential. Written and communication skills in English are required. International training will constitute an advantage.

Main activities:

• Lead experimental analyses, in collaboration with the team leaders.
• Design and stablish different experimental methodologies in the field (cell cultures, immune cell analyses, biochemical assays, NGS methods,…)
• Development and maintenance of experimental tools and computational tools (optional) needed for the project
• Perform, record and share the results of the analyses in standardised formats and reports. Record experimental information and analyses in laboratory notebooks in compliance with our institutions.
• Work in collaboration with wet-lab and dry-lab scientists in experimental design and sample collection for optimal analyses.
• Presentation of the progress of the project to team members. Attendance to international conferences for data sharing, collaboration and publication.
• Follow the technical evolutions and the development of the field
• Apply and enforce the regulations related to the activities of the field of study
• Training of other scientists in computational language and skills