진학프로석·박사 채용 접수 플랫폼

Our research goals
Our research group, headed by prof. Liselot Dewachter, is part of the de Duve Institute (UCLouvain, campus Woluwe, Brussels, Belgium).In our lab, we focus on the major human pathogen Streptococcus pneumoniae. We use genetics, molecular biology and microscopy to study processes that are fundamental for S. pneumoniae growth. By doing so, we hope to discover novel ways to kill this important pathogen and thereby help fight the ever-growing problem of antibiotic resistance.

Your project
We are looking for a postdoctoral researcher to work on our ERC-funded project “REalCYCLE”. In this project, we want to uncover how S. pneumoniae cell cycle processes (e.g. DNA replication, chromosome segregation, cell division) are regulated and how they are coordinated in response to each other to make sure that e.g. this bacterium divides exactly once per DNA replication round. You will perform genome-wide CRISPRi-seq screens combined with fluorescence-activated cell sorting (FACS) to select mutants of interest and/or focus on the bioinformatic analysis of these screening results. Based on the selected mutants and bioinformatic analyses, the underlying molecular mechanisms of cell cycle regulation will be determined.