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Dementia is the biggest health challenge of our century.

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

Today, over 1 million people in the UK are living with dementia and related neurodegenerative disorders, such as Parkinson’s disease. The impact of these incurable and progressive conditions on individuals and their families is devastating. The cost to the economy and public services is large and growing as the UK population ages. However, due to major advances in our understanding of the biology of these diseases, the scientific field is at a tipping point, with the next decade promising to deliver transformative breakthroughs in therapies and a new era of predictive, preventative, and precision medicine for neurodegenerative conditions. The UK Dementia Research Institute (UK DRI) is a globally leading multidisciplinary research institute of over 900 staff investigating the spectrum of neurodegenerative disorders causing dementia, driving a step change in our understanding of neurodegeneration, and accelerating the discovery, development and delivery of interventions that will help diagnose, treat, and ultimately prevent dementia.

About the role

We are looking to appoint a Research Assistant in Neurodegeneration in Dr Mallach’s research group focussing on understanding glial interactions during dementia development in neurodegeneration. Funded by ARUK, you will lead a project characterising the interactions of different cell types in human postmortem brain tissue. You will also develop workflows to analyse the generated images.

What you would be doing

You will use immunohistochemistry techniques and confocal microscopy to study the interaction of cells and proteins in human postmortem brain tissue. You will analyse the images using