진학프로석·박사 채용 접수 플랫폼

Context and Objectives

The aim of this multidisciplinary research program is to investigate the binding of anti–VCAM-1 antibodies through biodistribution studies of 64Cu-anti-VCAM-1 in preclinical models, both whole-body (PET imaging) and brain (autoradiography). The measured biodistribution will then be converted into predictive dose distribution, tumor control probability (TCP, in vitro studies), and normal tissue complication probability (NTCP). This first step will enable the determination of the optimal injected activity to maximize the TCP/NTCP ratio. Finally, an in vivo study using 212Pb-anti-VCAM-1 will assess treatment efficacy and toxicity at 50%, 100%, and 150% of the optimal dose.
This preclinical study involves collaboration between six multidisciplinary teams with expertise in physics, dosimetry, radiochemistry, preclinical imaging, brain metastasis models, radiobiology, molecular radiotherapy, pharmacology, and pharmacokinetics.

Expected outcomes: This project will provide essential data on VCAM-1–based alpha therapy for brain metastases, paving the way for first-in-human clinical trials.

Position description: The recruited postdoctoral researcher will be responsible for radiolabeling antibodies and conducting in vitro/vivo experiments.

Profile requirements:
- A PhD in oncology/neuro-oncology.
- Strong motivation, autonomy, curiosity, and commitment to developing a project at the interface of chemistry, biology, and physics.
- Ability to work in a multidisciplinary team with fluency in English.
- Experience in cell culture and animal experimentation applied to oncology.
- Experience in radiolabeling of proteins would be an asset, as would expertise in handling and characterizing antibodies and antibody-derived bioconjugates, including MALDI analysis.
- A diploma authorizing animal experimentation is required.

Expected skills: cell culture, animal experimentation, in vivo imaging (MRI and PET), histology, image analysis.