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The Laboratory of Single-Molecule Biophysics (website) at the International Institute of Molecular and Cell Biology (IIMCB), Warsaw led by Dr. Ewelina Małecka is seeking a highly motivated, creative, and independent Postdoctoral Researcher to join our team.

You will join the project entitled “Dynamics of RNA degrading complexes in bacteria” carried out as the SONATA BIS grant (2022/46/E/NZ1/00462) of the National Science Centre, Poland led by Dr. Ewelina Małecka.

ABOUT THE PROJECT:

Every RNA molecule in a bacterial cell lives a dynamic life - engaged in constant interactions with proteins, other RNAs, and the ribosome - until its inevitable degradation. How do these events coordinate in time and space? Why do some RNAs survive while others are rapidly destroyed? This project tackles one of the most fundamental questions in molecular biology: how do RNA silencing, translation, and degradation communicate with each other in real time?

Using single-molecule TIRF microscopy, biochemical reconstitution, and fluorescent labeling, we will watch individual RNA molecules and degradosome complexes at work, capturing millisecond-scale dynamics that shape gene expression.

Our goal is to reveal:

• How sRNAs and Hfq recruit the degradosome to specific mRNAs
• What determines whether an RNA is preserved or degraded
• How translation and decay compete or cooperate on the same transcript

The project will deliver a first mechanistic “movie” of RNA fate decisions in bacteria, information with broad implications for synthetic biology, RNA therapeutics, and gene regulation engineering.

More about the project: bit.ly/3yoVS3j