진학프로석·박사 채용 접수 플랫폼

Website of the lab: https://drinnenberg-lab.com/

ost Institution:

Institut Curie is a world-class multidisciplinary cancer research center linked to a hospital. The institute presents a vibrant research environment with access to numerous facilities including an advanced imaging platform, high-throughput next generation sequencing platform, proteomics and mass spectrometry, and bioinformatics.

Laboratory:

You will work in a dynamic research environment combining interdisciplinary approaches including genomics (ChIP-seq, Hi-C), proteomics and bioinformatics to study the evolution of centromeres and genome organisation in insects as model system. Our group consists of 7 enthusiastic and dedicated PhD students, researchers and engineers with expertise in both experimental and bioinformatic analyses. Among other funding sources, we were also awarded an ERC Starting and Consolidator grant for the research in our lab.

Project:

You will develop and lead an exciting project exploring the evolutionary plasticity and regulation of centromeres. In particular, the project aims to uncover the organization of unconventional centromeric organisation termed holocentromere (centromeric activity is distributed along the entire chromosomal length) and the diversity of kinetochore structures across insect species including Lepidoptera (butterflies and moths), many of which have lost the otherwise essential centromeric marker protein CENP-A. The work will combine genomic approaches, microscopy, and phylogenetic analyses, and will be carried out in collaboration with several groups providing access to a wide range of insect models.

Your profile

Curious, ambitious and enthusiastic. Open for new model systems to study new questions in biology

Independent. Your own ideas and creativity are always welcome!

If you have some experiences with computational data analyses will be a plus but is not absolutely required. Every project in the lab involves both computational and experimental approaches and people are encouraged to develop skills in both areas.

Relevant publications:

Yu C, Sankaranarayanan SR, Cornilleau G, Howes A, Azumaya C, Zilberley I, Brillantes B, Cheung TK, Dec L, Loew D, Tran P,Rose CM, Drinnenberg IA*, Ciferri C*, Yatskevich S*. Architecture and Function of Holocentric CENP-A-Independent Kinetochores (2025) bioRxivdoi: https://doi.org/10.1101/2025.07.14.664805* Co-correspondance

Marques A, Drinnenberg IA. Same but different: Centromere regulations in holocentric insects and plants. (2025) Current Opinion in Cell Biology. doi: 10.1016/j.ceb.2025.102484.

Sankaranarayanan SR, Ulmer J, Mørch A, Ali-Ahmad A, Sekulić N, Drinnenberg IA. Insects evolved a monomeric histone-fold domain in the CENP-T protein family (2024) bioRxiv https://doi.org/10.1101/2024.11.15.623767

Gil Jr J., Rosin LF, Navarrete E, Chowdhury N, Abraham S, Cornilleau G, Lei EP, Mozziconacci J, Mirny LA, Muller H*, Drinnenberg IA*. Unique territorial and sub-chromosomal organization revealed in the holocentric moth Bombyx mori (2024) bioRxiv https://doi.org/10.1101/2023.09.14.557757

Senaratne AP, Cortes-Silva N and Drinnenberg IA. Evolution of holocentric chromosomes: drivers, diversity, and deterrents. (2022) Seminars in Cell andDevelopmental Biology, 10.1016/j.semcdb.2022.01.003.

Senaratne AP, Muller H, Freyer KA, Kawamoto M, Katsuma S and Drinnenberg IA. Formation of the CenH3-deficient holocentromere in Lepidoptera avoids active chromatin. (2021), Current Biology, Oct 23:S0960-9822(20)31448-2.

Cortes-Silva N, Ulmer J, Kiuchi T, Hsieh E, Cornilleau G, Ladid I, Dingli F, Loew D, Katsuma S and Drinnenberg IA, CenH3-independent kinetochore assembly in Lepidoptera requires CCAN including CENP-T. (2020) Current Biology, Feb 24;30(4):561-572