진학프로석·박사 채용 접수 플랫폼

The Laboratory of Protein Metabolism (website) at the International Institute for Molecular and Cell Biology (IIMCB), Warsaw, led by Prof. Wojciech Pokrzywa, is seeking a highly motivated, creative, and independent Postdoctoral Researcher to join our team.

You will join the project entitled “Targeting Proteinopathies: Understanding and Mitigating the Effects of Pathogenic Mutations in Cullin-RING Ubiquitin Ligase Receptor” carried out as the Opus grant (2024/53/B/NZ3/02882) of the National Science Centre, Poland led by Prof. Wojciech Pokrzywa.

About the project:

Our research aims to uncover how ubiquitin signalling regulates protein stability and cellular homeostasis, with a particular focus on mechanisms disrupted in rare genetic diseases. By studying how specific mutations alter substrate recognition and degradation pathways, we seek to understand the molecular basis of protein accumulation and its pathological consequences. The Postdoctoral Researcher will focus on the cellular and biochemical aspects of these mechanisms, including analyses of patient-derived cell models carrying disease-associated mutations. The work will combine molecular biology, advanced microscopy, proteomics, and functional assays to characterise how ubiquitin-dependent regulation affects cell physiology. In addition, the position offers opportunities to explore side projects related to proteostasis and protein quality control, encouraging scientific creativity and cross-disciplinary collaboration in a dynamic, discovery-driven environment.