진학프로석·박사 채용 접수 플랫폼

We are looking for a candidate to apply for a Research Fellowship (funded by a MSCA granty – TALENTGAL) in the Gene Regulatory Control in Disease Laboratory at the Center for Research in Molecular Medicine and Chronic Diseases (CiMUS)/University of Santiago de Compostela in Spain.

Using both experimental and computational approaches, our laboratory aims to uncover the mechanistic basis of gene expression control in developmental and pathological contexts, from individual genes to whole genomes. We investigate multiple layers of gene expression regulation, including transcriptional, translational, and post-translational mechanisms, with a particular focus on nerve disorders. I

Selected candidates will join a multidisciplinary team comprising computational, molecular, and cellular biologists.

The laboratory is funded by the European Commission (ERC Consolidator Grant) and the Spanish Ministry of Science, as well as private foundations (AECC).

Project:

The myelin sheath is essential for neuronal function and health: myelinating glial cells speed up propagation of axonal potentials, fuel the energetic demands and regulate the ionic environment of neurons. Lesions to the myelin sheath thus result in devastating neurological disorders that include multiple sclerosis, diabetic neuropathy and Charcot-Marie-Tooth disease. On the other hand, Schwann cell plasticity i.e. their ability to breakdown myelin and subsequent de-differentiation, can actually be beneficial in other situations, namely in peripheral nerve regeneration. Peripheral nerves have a striking ability to regenerate after injury, whereby axons can grow readily back to their targets, redundant myelin is removed and new myelin formed around regenerated axons, with the result that nerve tissue that is broadly normal in structure and function, is restored in a surprisingly short time.

There is emerging evidence, enabled by modern techniques, that ribosomes, typically viewed as invariant, passive molecular machines, may instead be heterogeneous in composition, with particular ribosomal components having a ‘specialized’ regulatory capacity for preferential translation of specific mRNAs. In this project (MyeRIBO, financed by an ERC Consolidator grant) we propose that translation control by specialized ribosomes is a novel layer of regulation that shapes the proteome of the myelinating glial cell during myelination and in nerve repair. The candidate, in collaboration with leading European groups, will exploit advances in cryo-EM and quantitative proteomics analyses to discover the nature and diversity of ribosomes in myelinating cells, employ genome-wide ribosome profiling to obtain mechanistic insights into selective mRNA translation by heterogeneous ribosomes, and generate genetic mouse models to determine the functional consequences of this specialization for myelination in vivo. MyeRIBO will push further the boundaries of our current understanding of the molecular control of myelination, which could have a profound impact for understanding neural development and myelin disorders.

Key publications:

1. 1. Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination. Sci Adv. 2024 Apr 12;10(15):eadm7600.
2. 2. Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting. Cell Metab. 2023 Aug 8;35(8):1373-1389.e8

Eligibility conditions

• • MSCA mobility rule:Applicants must not have resided or carried out their main activity (work, studies, etc.) in Spain for more than 12 months in the 36 months immediately prior to the call deadline.
• • Doctoral degree requirement:Applicants must hold a doctoral degree at the call deadline, or have successfully defended their PhD thesis and be awaiting formal award of the degree, in accordance with the MSCA-COFUND-2025 Guide for Applicants.
• • Postdoctoral experience limit:Applicants must have obtained their doctoral degree within the eight years prior to the call deadline, excluding duly documented career breaks, in line with MSCA guidelines.
• • Minimum scientific output:At least two peer-reviewed publications (published or accepted), of which at least one must demonstrate a significant contribution by the applicant (e.g. as first or corresponding author).