진학프로석·박사 채용 접수 플랫폼

KEY WORDS:             RNA biology, neurodegenerative diseases, alternative splicing, polyadenylation, RNA structure, non-coding RNAs, RNA-seq, neurons

Research topic:             RNA-polyQ: RNA processing and dysregulation in polyglutamine diseases – insights into pathogenesis and therapeutic targets

Principal Investigator:  dr hab. Agnieszka Fiszer

Department’s website: https://portal.ichb.pl/department-of-medical-biotechnology/

I. Project description

SONATA BIS project from National Science Centre (2025/58/E/NZ2/00248)

More than 30 years have passed since the discovery of the genes whose mutations are responsible for neurodegenerative polyglutamine (polyQ) diseases. However, the mechanisms leading to pathology in the brain are not fully understood which makes it difficult to develop effective treatment. A thorough investigation of disruptions in cellular RNA levels and function is a key step toward understanding the molecular pathways altered in disease development.

RNA molecules of various types exert functions crucial for each cell's functioning. In this project, we will explore RNA processing pathways and RNA dysregulation in selected polyQ diseases. We will investigate mutant mRNAs and other selected RNAs (including long non-coding RNAs, circular RNAs and microRNAs) in terms of their cellular processing, modification, localization, as well as presence in extracellular vesicles. A set of human cellular models (also of neuronal type) with endogenous or exogenous expression of polyQ disease-related genes will be used to reveal RNA dysregulation profiles and characterize selected RNAs. Finally, we will validate specific observations in patients’ samples and propose novel therapeutic strategies based on identified hallmarks.

We offer the following opportunities:

- conducting scientific research in a stimulating and friendly environment, in a scientifically vibrant Institute,

- to develop and strengthen your skills in a specialized medical biotechnology area, using advanced research techniques,

- to participate in training and conference trips and visits to collaborating laboratories.