진학프로석·박사 채용 접수 플랫폼

A tender is hereby opened for the award of 1 (one) Postdoctoral Fellowship (PDF) in the scope of R&D projects New Routes for Anticancer Metallodrugs - Drug2Target COMPETE2030-FEDER-00672800, within the Instituto de Biomedicina da Universidade de Aveiro (IBIMED) under the following conditions:

1. Scientific Area: Biochemistry

2. Funding Source Foundation for Science and Technology/MCTES, I.P., through national funds (PIDDAC), co-financed by the European Regional Development Fund (ERDF) of the European Union, through the COMPETE2030-FEDER-00672800 of Portugal 2030

3. Admission Requirements: Doctor Degree in Biochemistry

4. Other Requirements: Prior experience in Nuclear Magnetic Resonance (NMR) spectroscopy, including independent operation and contribution to equipment maintenance, particularly for metabolomic analysis of biological systems (tissues, cells, biofluids). Prior experience with advanced multivariate statistical analysis methodologies and the use of software packages such as Matlab, SIMCA, R, Chenomx, and MetaboAnalyst, as well as relevant databases. FELASA training and experience in animal experimentation, alongside experience in 2D and 3D cell culture. Specific experience with platinum and palladium metallodrugs and cancer research, supported by projects and scientific publications.

5. Eligibility: Applicants are eligible if they comply with paragraph b) of nos.1 and 2 of article 2, of the Research Fellow Statute as amended by Decree-Law no. 123/2019, of August 28th, as well as in article 7 of the Research Grant Regulations of the Foundation for Science and Technology. PDFs can only be granted provided the following requirements are met cumulatively:

a) The doctorate has been obtained within the three years prior to the date of submission of the application for the grant;
b) The postdoctoral research is carried out in a host entity different from the entity where the research work leading to
the doctoral degree was carried out;
c) the research activities do not require postdoctoral experience;
d) the research activities have a time frame for development and implementation of three years or less;

e) The fellow does not exceed, with the conclusion of the grant contract in question, including possible renewals, an
accumulated period of three years in that type of grant, consecutive or interpolated.

6.Work plan: The work plan, part of the Drug2Target project, aims to contribute to the development and preclinical evaluation of new platinum-, palladium-, and nickel-based anticancer metallodrugs, using metabolomics approaches based on Nuclear Magnetic Resonance (NMR) spectroscopy and the integration of results with biological and pharmacological assays. The fellow will develop research activities related to the preparation and processing of biological samples, including tissues, two-dimensional (2D) and three-dimensional (3D) cells, and biofluids, for metabolomics analysis by NMR. They will also be responsible for the acquisition, processing, and quality control of spectroscopic data, as well as their multivariate statistical analysis and biological interpretation, using specific computational tools, namely Matlab, SIMCA, R, Chenomx, and MetaboAnalyst. Activities include participation in in vitro and in vivo studies aimed at evaluating the therapeutic efficacy, toxicity, and mechanisms of action of new metal compounds. The fellow will contribute to the integration of metabolic data with results obtained through other cellular and molecular biology methodologies, allowing the identification of metabolic biomarkers, altered metabolic pathways, and potential therapeutic targets associated with the response to new antitumor agents. Participation is also expected in the implementation and optimization of experimental methodologies, the integrated processing and interpretation of results, the preparation of technical-scientific reports, the preparation of manuscripts for publication in international scientific journals, and the presentation of results at project meetings and national and international conferences. Given the multidisciplinary nature of the project, the scholarship recipient is expected to have advanced training in Biochemistry and experience in NMR metabolomics, multivariate statistical analysis, cell cultures and in vivo experimental models, also valuing knowledge in bioinformatics, molecular biology and integration of omics data. The ability to work in multidisciplinary teams, autonomy in the execution of experimental protocols, critical thinking in the analysis of results, and aptitude for written and oral scientific communication are also expected. The results of this work plan should contribute to deepening the knowledge of the metabolic mechanisms associated with the action of new anticancer metallodrugs and to the development of innovative, more effective and less toxic therapeutic strategies, in line with the scientific objectives of the Drug2Target project.

7. Applicable legislation and regulations: Statute of Scientific Research Grant Holder, as amended by Decree-Law no. 123/2019, of August 28th; Regulation no. 950/2019, of November 29th, published in Diário da República, no. 241, Series II, of December 16th (FCT, I.P. Research Grants Regulation); Decree-Law no. 66/2018, of August 16th (Legal regime for recognition of academic degrees and diplomas of higher education awarded by foreign higher education institutions).

8. Workplace: The work will be carried out at Instituto de Biomedicina da Universidade de Aveiro (IBIMED) of the University of Aveiro, under the scientific supervision of Professor/Doctor Luisa Alejandra Helguero.

9. Duration of the grant(s): The grant duration will be 12 months, starting in September 2026, and may be renewed for additional periods of 3 months up to the maximum funding approved, and may under no circumstances exceed the limits defined in the Regulations for the type of grant in question, in accordance with Article 7 of Regulation No. 950/2019, of November 29th, published in the Diário da República, No. 241, Series II, of December 16th (FCT, I.P. Research Grants
Regulation).

10.Amount of monthly maintenance allowance: The amount of the grant corresponds to €1.901,00 according to the table of monthly maintenance allowance amounts set out in Annex I of Regulation no. 950/2019, subject to any updates that may be applicable, under the terms of no. 2 of article 18 of Regulation no. 950/2019, of November 29th, published in Diário da República, no. 241, Series II, of December 16th (Research Grants Regulation of FCT, I.P.). The fellow may also be reimbursed for the amount corresponding to the Voluntary Social Security, in case of adherence to this plan.

11. Selection methods: The selection methods to be used will be the following: curriculum vitae assessment (evaluated from 0 to 20), interview (evaluated from 0 to 20, in person or remotely, with 20-30 min duration), with the respective value of 90% and 10%.

12. Composition of the Selection Jury:
President: Professora Doutora Luísa Alejandra Helguero, Professora Auxiliar da Universidade de Aveiro;
Jury members:
Professor Doutor Paulo Jorge de Almeida Ribeiro Claro, Professor Associado com Agregação da Universidade de Aveiro;
Professor Doutor Brian James Goodfellow, Professor Auxiliar com Agregação da Universidade de Aveiro.
Substitute members:
Doutora Mariana Braga de Oliveira, Investigadora Auxiliar, da Universidade de Aveiro.
Doutora Mariela Martins Nolasco, Investigadora Auxiliar da Universidade de Aveiro.

13. Deadline for applications (not be less than 10 working days) and how to submit applications: The call is open from 21-07-2026 to 03-08-2026, and only applications submitted within the deadline will be admitted.

Applications must be formalized by sending a letter of application accompanied by the following documents: Curriculum Vitae, certificate of qualifications, declaration of honor and other supporting documents deemed relevant. They shall also indicate the e-mail address to which by such indication they accept to be notified for all purposes within this procedure.

Applications should be sent by e-mail to [email protected].

14. Form of publication/notification of results: The final results of the evaluation will be published through an ordered list by final mark posted on the University's website, within 90 working days after the final date of submission of the application, and the successful candidate will be notified by email. For the purposes of prior hearing of interested parties, the deadline of 10 working days is set, as provided for in the Code of Administrative Procedure. At the end of the period
for hearing the interested parties, and in the absence of any response from them, the list of candidates will become final. Candidates may lodge a complaint against the final decision within 15 working days, or appeal to the maximum executive body of the funding entity within 30 working days after notification of the final decision, in accordance with the provisions of article 12 of the Research Grants Regulation of the Foundation for Science and Technology.

15. Tender duration: The final ranking list of candidates will be valid until 31-08-2026 for the purpose of constituting a reserve list for selection.

Obs:

The proof of enrolment must be made available until the contract is awarded, and the candidate may attach a declaration of honor to confirm that they meet the requirements for enrolment in an integrated master's degree, master's or doctoral program or in a course that does not confer an academic degree.

If the qualification has been conferred by a foreign higher education institution it must be recognized by a Portuguese higher education institution, under the terms of the provisions of article 25 of Decree-Law no. 66/2018, of August 16th, which approves the legal regime of recognition of academic degrees and diplomas of Higher Education, attributed by foreign higher education institutions, and of paragraph e) of no. 2 of article 4 of Decree-Law no. 60/2018, of August 3rd, and any formalities established therein must be fulfilled by the date of the hiring act.