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Job Title: Central Bioinformatician - PRISM

Department: Endocrine Oncology Research Group (EORG) within the Dept of Surgery, RCSI

Reporting to: Professor Leonie Young and Dr Damir Vareslija

Location: Beaumont RCSI Cancer Centre

Contract/Duration: Specified purpose contract, up to 2.5 years

Remuneration: Salary in line with IUA Research Salary scale, subject to experience

Closing Date: 16th of January 2026

RCSI is a community of academic, research, clinical and professional staff working collaboratively to lead the world to better health. Here, you will thrive in an innovative and inclusive atmosphere and your personal development and wellbeing will be supported. We invite you to join us to help deliver on our exciting mission “To educate, nurture and discover for the benefit of human health”. We seek candidates whose experience to date has prepared them to contribute to our commitment to the “Race Equality Action Plan 2025-2029” at RCSI. Our students come from all walks of life and so do we. We hire great people from a wide variety of backgrounds. This makes our university stronger and ensures we hire the best talent.

Innovating for a Healthier Future 2023-2027 is RCSI’s new five-year strategic plan. Through it, RCSI will enhance human health by meeting the health workforce needs of society, creating the insights and inventions that drive health improvements, and working in partnership with patients and the public in support of better health and well-being for all. The strategy unites the RCSI community in supporting the UN Sustainable Development Goals – with a particular focus on Goal 3, which targets good health and well-being.

For each of the last six years, RCSI has been positioned in the Top 300 of universities worldwide in the Times Higher World University Rankings. We are proud that RCSI ranks first in the world for “Good Health and Well-being” in the Times Higher Education #SDG #SDG Impact Rankings 2025. This reflects our commitment to supporting people of all ages to live healthy lives and our work to promote the concepts of well-being and positive health. In 2024, RCSI was delighted to be named one of the Sunday Times Best Places to Work in Ireland.

At RCSI, our core values of Respect, Collaboration, Scholarship, and Innovation are at the heart of everything we do. We are committed to creating an inclusive and supportive environment where every colleague is valued and empowered to thrive. Our dedication to these values ensures that we foster a culture of mutual respect, open collaboration, continuous learning, and innovative thinking. Join us at RCSI, where your contributions will be recognised, and you will be part of a dynamic team making a real impact on global health.

Overall Purpose of the Position

The primary purpose of this role is to lead the processing, analysis, and reporting of all sequencing data generated under the Research Ireland-funded PRISM programme. A key component of the role will be PRISM Clinical Reporting, specifically the analysis of TSO500 gene panels performed on patient tumour samples in the Molecular Pathology Laboratory, an INAB-accredited laboratory, using the Illumina NextSeq platform. Actionable targets identified will be reported back to the treating physician to support clinical decision-making.

The role also covers research-driven sequencing, including whole exome sequencing (WES), transcriptomics, and epigenetics data analysis. This position requires the development and maintenance of bioinformatics pipelines and close collaboration with clinical teams, research groups, and clinical genomics scientists appointed under the PRISM grant.

Role Requirements

Candidates should hold a PhD in Bioinformatics/Computational Biology. Experience with processing, analysis and visualisation of DNA and RNA sequencing data is essential. Candidates should be enthusiastic and willing to work on research projects as part of a multidisciplinary team of scientists and clinicians.

Specifically, the duties of the post are:

• • Clinical Genomics Analysis and Reporting (PRISM Clinical Reporting)
• • Lead the bioinformatics analysis and interpretation of TSO500 gene panel data from patient tumours.
• • Work with the Molecular Pathology Laboratory to ensure seamless data transfer, analysis, and reporting to treating physicians.
• • Ensure compliance with INAB-accredited workflows for clinical genomics reporting.
• • Work closely with clinical teams, researchers, and PRISM clinical genomics scientists to align data analysis approaches with clinical and research objectives.
• • Provide bioinformatics expertise to support study design, data interpretation, and publication efforts.
• • Ensure data handling practices comply with institutional, national, and international regulations for patient data and research data.
• • Document processes and results to meet both clinical accreditation and research publication standards.
• • Integrative analysis of multiple next-generation sequencing data sets, in particular Exome Sequencing (DNA and RNA), ChIP-Seq and Methylation sequencing data (DNA / RNA)
• • Development of pipelines for processing, analysis and visualisation of NGS data
• • To drive pathway discovery and identify novel targets in metastatic breast cancer
• • To create visually impactful representations of data for publications and presentations
• • To supervise and mentor postgraduate students as required
• • Contribute to the preparation of high-impact peer review scientific publications and to disseminate research findings at national and international meetings
• • Provide as required, bioinformatics resources for day-to-day use by members of the research team.

Qualifications:

• • A PhD in bioinformatics /biostatistics/computer science with research in a relevant scientific area
• • Minimum second class (2.1) honours degree in a relevant subject

Knowledge and Experience (Essential):

• • Demonstrated use of programming or statistical computing languages (e.g. R, Perl, Python, Java, C++ etc.)
• • Visualisation of high-dimensional data
• • Experience of working with Unix/Linux operating systems.
• • Experience with the application of statistical approaches to biological problems (e.g. statistical testing, linear models)
• • Experience with application of machine learning methods and mining of large scale public datasets
• • Proven ability to work independently and as an effective team member
• • Ability to communicate effectively
• • Strong organisational skills with the ability to produce results and prioritise tasks

We are all too aware that imposter syndrome and the confidence gap can sometimes stop fantastic candidates putting themselves forward, so please do submit an application — we’d love to hear from you.

Application Process

Please apply online through the RCSI careers portal before the closing date with your CV and cover letter.

Informal Enquiries can be directed to Dr Damir Vareslija at damirvareslija@rcsi.ie

Please note we do not accept CVs emailed directly.

Garda vetting and occupational health review may be required for this role, depending on the nature of the duties and responsibilities. Further information will be provided during the recruitment process.

Eligibility to Work in Ireland

Visa sponsorship is available for candidates who fully meet the essential criteria of the role. Candidates who require a work permit or hosting agreement are welcome to apply.

Proof of eligibility documentation will be required at a later stage in the recruitment process. Please note that sponsorship is subject to approval by the relevant Irish authorities and role-specific eligibility.