Institute of Bioorganic Chemistry Polish Academy of Sciences
Post-doctoral reseaecher - Call for applications
접수중2025.12.23~2026.01.26
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접수 기간
2025.12.23 00:00~2026.01.26 23:59
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생명과학, 생물학, 동물・수의학, 축산학, 작물・원예학, 식품가공학, 농업학, 수산학, 산림・원예학, 농림수산환경생태학, 농림수산바이오시스템공학, 생명공학, 한약학, 약학더보기
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연구기관
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연봉 정보
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KEY WORDS: amyotrophic lateral sclerosis, frontotemporal dementia (ALS/FTD), pathogenesis of ALS/FTD, RNA-protein interactions, cryogenic electron microscopy, crystallography, structural biology
Principal Investigator: dr hab. Agnieszka Kiliszek
Research topic: A comprehensive structural and functional analysis of toxic RNA-protein interactions for better understanding and therapeutic targeting of amyotrophic lateral sclerosis and frontotemporal dementia
I. Project description
We offer a position as an assistant professor (post-doc) within the OPUS-28 (LAP) project, carried out in close collaboration with the Slovenian group led by Prof. Boris Rogelj from the Jožef Stefan Institute in Ljubljana, entitled: “Comprehensive structural and functional analysis of toxic RNA–protein interactions to improve understanding and therapeutic targeting of amyotrophic lateral sclerosis and frontotemporal dementia.”
Our research focuses on the complex pathogenesis of two genetic diseases, ALS and FTD. In particular, we are interested in “toxic” RNA molecules whose structure and interactions with proteins located in the nucleus and cytoplasm lead to the dysfunction of nerve cells and, ultimately, to their death. Despite numerous studies, including our own, on the toxic RNA–protein interactome and the identification of more than a thousand proteins, the structural and mechanistic details of these interactions remain unknown. So far, no atomic model has been identified for complexes between mutated transcripts and the aggregation-prone proteins bound to them. Due to the large knowledge gap in this area of structural interactome research, the results obtained will have significant cognitive impact and strong potential for publication in high-impact-factor journals.
In this project, we will apply interdisciplinary approaches in structural biology (cryo-electron microscopy, cryoEM; crystallography), biophysical and biochemical methods, as well as functional studies conducted on human cells.
Benefits
- • The estimated gross salary is ca. 9 450,00 PLN/month.
II. Requirements for the candidates
- • A PhD degree in biology or chemistry or a related discipline.
- • Well-documented research output in the form of research papers (Web of Science).
- • Experience in applying biophysical and biochemical evaluation of biomolecules and the ability to work with RNA molecules and/or proteins (RNA synthesis, protein expression and purification; integrity and homogeneity analysis, etc.).
- • Knowledge in the areas of molecular biology, structural studies of biomolecules, RNA–protein interaction studies, the use of tools for generating in silico models, and issues related to the project’s subject matter.
- • Ability to plan and conduct experiments and to visualize results.
- • Ability to make responsible decisions without supervision and adaptation to teamwork.
- • English language proficiency enabling effective communication, reading of scientific literature, and preparation of publications.
- • Experience in crystallographic analysis or cryoEM will be considered an advantage, but is not a prerequisite.
*According to NCN requirements, only individuals who obtained a doctoral degree no earlier than 12 years before the year of employment in the project may be admitted. This period may be extended by the time spent on long-term (over 90 days) documented sickness benefits or rehabilitation benefits due to incapacity for work. Additionally, the period may be extended by the number of months spent on leave for the care and upbringing of children, as specified under the Labor Code. For women, this period may also be increased by 18 months for each born or adopted child if this method of accounting for breaks in the scientific career is more advantageous.
Furthermore, according to NCN requirements, individuals who obtained a doctoral degree at an institution other than the Institute of Bioorganic Chemistry of the Polish Academy of Sciences, or those who earned the degree at ICHB PAN but completed a continuous, documented postdoctoral internship of at least 10 months at an institution other than the project-implementing entity and in a country different from where the doctoral degree was obtained, may be admitted.
III. Duties in the project
- • Designing and conducting experimental work.
- • Preparing RNA–protein complexes for structural analysis and for biophysical and biochemical evaluation.
- • Biophysical and biochemical evaluation of RNA–protein complexes.
- • Crystallographic or cryo-EM analysis (after training) of RNA–protein complexes.
- • Processing and interpreting results, preparing summaries/reports, and scientific publications.
- • Supervising the work of students/PhD candidates, presenting results at seminars, scientific meetings, and conferences.
IV. Required documents
- • Cover letter of application to the Director of IBCH PAS featuring contact details to at least two referees.
- • Copy of the doctoral diploma.
- • CV featuring information on the candidate's scientific track record, including:
- - the list of papers published in journals listed in the Web of Science (WoS) database, stating the IF in accordance with WoS, number of citations and the H-index;
- ◦ list of patents;
- ◦ information on the previously managed projects or participation in project implementation;
- ◦ information on the accomplished research internships;
- ◦ information on the awarded prizes and distinctions.
V. Applications
Applications should be submitted via the eRecruiter portal at: Click here
VI. Submission Deadline
• 26.01.2026
근무 예정지
대표해외(폴란드) : Poland, Institute of Bioorganic Chemistry, PAS, Poznań, 61-704, wielkopolska, Zygmunta Noskowskiego 12/14
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Institute of Bioorganic Chemistry Polish Academy of Sciences
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