진학프로석·박사 채용 접수 플랫폼

The Neurobiology Laboratory has reached a new agreement with the Swedish company Umecrine, which has subcontracted it to carry out part of the study “Neurosteroid mediated control of sleep comorbidities in Parkinson's Disease,” funded by a grant from the Michael J. Fox Foundation (Grant ID MJFF-025484). This entails an occasional, unforeseen increase in workload, making it necessary to hire a person to participate in this study for a period of eight months, performing some of the following tasks:

• • Evaluation of fatigue and motor and cognitive functions in rats using different behavioral tests: fatigue (Treatmill), motor coordination and locomotor gait (using the Catwalk and Motorater equipment), spatial memory test (Y-maze). The software Anymaze to acquisition and analysis of behavior will be used for this purpose.
• • Administration of golexanolone treatment to rats through intragastric feeding tubes.
• • Dissection and processing of the tissue (striatum, substantia nigra and cerebellum) for subsequent analysis (fixation, homogenization).
• • Immunohistochemistry to analyze the content of tyrosine hydroxylase and alpha-synuclein, neuronal death and activation of microglia and astrocytes, in the striatum and substantia nigra.
• • Analysis of the content of GABAA receptor subunits and dopamine receptors in the striatum and substantia nigra by Western blot.
• • Statistical analysis and representation of data using Excel and GraphPad Prism softwares.
• • Preparation of results for presentation in Conferences and in scientific articles.
• • Other related tasks

Basic requirements of the position:

• • Required qualification: PhD in Neuroscience or a similar area at the time of starting the contract.
• • Accreditation for carrying out experiments on animals
• • High level of English, both spoken and written

Experience required:

• • Research experience in Neuroscience
• • Experience in carrying out and analyzing motor and cognitive tests in rats
• • Experience in analysis of neuroinflammation and related mechanisms