진학프로석·박사 채용 접수 플랫폼

VICE-RECTOR in Charge of the School of Natural Sciences / for Finance and Research Projects at the Adam Mickiewicz University, Poznań announces a competition for the position of:

Post-Doctoral Researcher

at the Center for Development of Gene Therapies TREAT-EXP

in the project FENG.02.01-IP.05-M038/25, TREAT-EXP: Development of therapeutic strategies for human genetic diseases caused by nucleotide repeat expansions.

The FENG.02.01-IP.05-M038/25 project is carried out within the 2.1 MAB FENG call 2/2025 programme of the Foundation for Polish Science co-financed by the European Union under the European Funds for Smart Economy 2021-2027 (FENG).

A post-doctoral researcher position in a research group at the newly established Center for the Development of Gene Therapies at Adam Mickiewicz University.

We are seeking a postdoctoral researcher to join the research group of dr. hab. Michał Gdula to work on leveraging epigenetics to improve the effectiveness of genetic therapies for diseases caused by nucleotide repeat expansions (including myotonic dystrophies), within the framework of the International Research Agenda (MAB) FENG grant funded by the Foundation for Polish Science (FNP).

Dr. hab. Michał Gdula’s group is one of four teams participating in the TREAT-EXP project, led by Prof. Krzysztof Sobczak and funded by FNP with PLN 30 million over four years. The overarching goal of TREAT-EXP is to build a research platform to develop therapeutic strategies and identify active compounds targeting pathogenic products of mutated genes—either toxic RNA or toxic proteins—responsible for DM, FXPAC, and ALS.

The goal of Michał Gdula’s team is to increase the efficacy of therapies for DM1 and DM2 by modulating epigenetic regulation using modified antisense oligonucleotides (ASOs). DM1 is caused by a CTG expansion in the 3′UTR of the DMPK gene, while DM2 results from a CCTG expansion in an intron of the CNBP gene; the resulting toxic repeat-expanded RNA forms nuclear foci and sequesters MBNL proteins, leading to widespread alternative splicing defects and multiple multisystem symptoms.

The postdoc’s tasks will include characterizing the epigenetic landscape of DM-associated genes and mapping their regulatory elements in cellular models using genomic methods (e.g., ATAC-seq, CUT&RUN, Capture-C, Micro-C). Next, in collaboration with—and drawing on the expertise of—Prof. Sobczak’s group, ASOs will be designed to target selected regulatory elements in order to reduce DMPK/CNBP expression or increase the expression of MBNL genes.

We offer a position in a well-funded, interdisciplinary environment at the Center for Development of Gene Therapies (Adam Mickiewicz University), located in the modern Center for Advanced Technologies building.

A brief project description can be found at: https://ibmib.web.amu.edu.pl/mab-feng-grant/

Anticipated job starting date: May 1, 2026

Fixed-term contract for 12 months, with the possibility of extension until December 31, 2029,

Monthly salary: PLN 13 866 gross

Informal inquiries welcome: michal.gdula@amu.edu.pl