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The research group of Genome (In)stability and Mammalian Physiology (https://www.garinislab.gr/) under the Hevolution Foundation Geroscience Research Opportunities program (Project ID HF-GRO-23-119921), entitled “Targeting genome stability as root cause of aging” (Program Coordinator Prof. George Garinis) invites applications for one (1) postdoctoral researcher position.

About the lab

The Garinis lab investigates the impact of DNA damage on mammalian physiology during aging and its causative role in the premature onset of age-related diseases. We are using genetically engineered mouse models that carry inborn defects in Nucleotide Excision Repair and/or transcription as well as mice that carry tagged versions of proteins involved in DNA repair and/or transcription in combination with high-throughput, biochemical, molecular and cellular biology methods. This approach allows us to understand how mammalian cells exploit their natural defense strategies to counteract DNA damage-driven pathologies and prolong healthspan.

About the project: 

DNA damage constantly occurs and requires a range of DNA repair systems to maintain genome integrity. While the role of impaired DNA repair and DNA damage accumulation in causing age-related diseases have been intensely investigated, improving overall DNA repair capacities have remained elusive. Our recent discovery of the DREAM complex as a master regulator of DNA repair capacities has revealed a mechanism that could enhance overall genome stability. This research program focuses on uncovering the mechanisms of DNA repair gene regulation, exploring the fitness costs of enhanced somatic DNA repair and establishing in vivo how augmented DNA repair through DREAM inhibition could extend healthspan in mammals. 

Job Description: 

A highly motivated and experienced postdoctoral research scientist will participate in the project titled “Targeting Genome Stability as the Root Cause of Aging”, focusing on addressing the evolutionary trade-off of somatic DNA repair capacities and on investigating DREAM dysfunction in the DNA damage response in mice. The successful candidate should hold a BSc, MSc and PhD in Biology, Medicine, Life Sciences or related fields, and prior documented experience in molecular/cellular biology methods, imaging techniques, extracellular vesicles isolation and modification approaches and mouse genetics. Candidates with previous laboratory experience in the aging, DNA damage and repair research fields will be prioritized. Prior working experience in biochemistry assays will be highly appreciated. Presentation, communication, collaboration, excellent scientific authoring and project management skills are pluses. S(he) should also have a strong publication record in peer reviewed journals in related research fields and fluency in English (written and oral).