진학프로석·박사 채용 접수 플랫폼

The successful candidate will carry out projects focused on the investigation of glioblastoma pathogenesis, particularly the mechanistic basis of the emerging causal role played by the Human Cytomegalovirus in brain cancer development. The project will combine the use of cell and molecular biology, signalling, diverse omics approaches including metabolomics, proteomics, DNA and RNA sequencing, high-content microscopy, gene manipulation, virology and cell culture as well as animal models. The candidate is expected to closely collaborate with other members of the team and with our collaborators on this project at the Karolinska Institute in Stockholm and University of Turku, participate in scientific conferences, help supervise students and be involved in writing publications.

The Danish Cancer Society has its own research institute, consisting of 23 research groups and several core facilities, with around 250 researchers dedicated to basic, translational and epidemiological cancer research, at an internationally highly competitive level. The Genome Integrity Group headed by Professor Jiri Bartek focuses on mechanistic understanding of genome stability, cell cycle control, DNA damage response and deregulation of these fundamental processes in cancer development, including discovery of tumour cell-selective stress-tolerance mechanisms that provide cancer cell vulnerabilities targetable by innovative treatments. 

While this open project will focus on brain tumours and the role of the Human cytomegalovirus in glioblastoma pathogenesis, the group has broad expertise in diverse human cancer types and fields of cell and molecular biology, signalling, biochemistry, bioinformatics, metabolomics, biomarkers and new treatments, including drug repurposing. We have discovered several important cell cycle and genome integrity checkpoint pathways, and pioneered concepts such as the role of replication stress, G1/S control and DNA damage response in cancer development, often published in recognised journals such as Nature, Science or Cell. We have a broad international collaborative network, and the selected candidate(s) will benefit from visits at our collaborating laboratories in Sweden and Finland