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Position description

Position identification 

Title of post : Post-doctoral position in Drosophila genetics/cell biology

Type of contract : Fixed-term contract funded by the European Research Council (ERC) project Evo-Immuno

Category (A,B or C) :  A

Contract/project period : 1 year  Expected date of employment : 1/7/2025

Proportion of work : Full-time

Workplace :  Institut de Biologie Moléculaire et Cellulaire (CNRS), University of Strasbourg, France

Desired level of education : PhD in relevant fields such as genetics, cell biology, or related disciplines

Experience required : Expertise in Drosophila genetics and cell biology

Contact(s) for information on the position (identity, position, e-mail address, telephone) :  Bénédicte Stévenin, Administrave contact, m3i-sec@ibmc-cnrs.unistra.fr 

Date of publication : 02/05/2025

Closing date for the receipt of applications : 30/05/2025

Research project or operation 

The post-doctoral project aims to investigate the function of genes regulated by the STING pathway in Drosophila species and other arthropods, focusing on genes involved in regulation of a transcription factor of the NF-kB family. The objective is to understand, using cell and molecular biology methods, the signaling events connecting STING to NF-kB activation. The focus will be to:

• Identify genes regulated by the NF-kB protein Relish in response to activation of the STING pathway.
• Characterize the mechanism of recruitment of Relish to the promoter of these genes.
• Decipher the mechanism of activation of Relish by STING, leading to its nuclear translocation and activation of gene expression.
• Use genetics to validate in vivo the involvement of the identified factors in STING signaling. 

 Activities 

• Description of the research activities :
• Realize experiments in tissue culture cells (transfections, gene knock-out, immunoprecipitations).
• Generate and analyze DNA and RNA sequencing data to identify candidate genes regulated by Relish.
• Perform functional characterization of STING-regulated genes in Drosophila and in cell lines.

Related activities : 

• Collaborate with national and international research teams.
• Contribute to the publication of scientific articles.
• Engage in lab meetings and present research findings.

 Skills       

• Qualifications/knowledge :
• Strong foundation in cell biology.
• Knowledge of Drosophila as a model organism.
• Expertise in Drosophila genetics
• Familiarity with innate immune pathways and STING signaling.

• Operational skills/expertise :
• Expertise in molecular and cellular biology techniques, genetic manipulation.
• Basic competence in data analysis and bioinformatics (e.g., RNA sequencing), with the possibility to improve or develop further skills in collaboration.
• Ability to design and conduct experiments independently.

• Personal qualities :
• Strong organizational and time management skills.
• Effective communication and teamwork abilities.
• Enthusiasm for exploring evolutionary biology and innovative research.

 Environment and context of work 

• Presentation of the laboratory/unity : 

The position is hosted by the Institut de Biologie Moléculaire et Cellulaire (CNRS) on the central campus of the University of Strasbourg. The research team is coordinated by Jean-Luc Imler & Carine Meignin is part of an international collaborative network.

The selected candidate will join a multinational team entitled "Antiviral innate immunity in Insects  : Evolutionarily conserved mechanisms and innovations" within the laboratory “Insect Models of Innate Immunity”, one of three laboratories hosted by the Institute of Molecular and Cellular Biology located on the central campus of the University of Strasbourg, France.  This unit is dedicated to the study of molecular and cellular bases of anti-infectious defense, using as a model the fruit fly drosophila (Drosophila melanogaster) or mosquitoes.

• Hierarchical relationship : 

 Reports to the principal investigators, Jean-Luc Imler & Carine Meignin

• Special conditions of practice (notice attached): 

The role may require travel to partner laboratories.

To apply, please send your CV, cover letter and diploma to : 

Applicants should send the following documents via email to Bénédicte Stévenin (m3i-sec@ibmc-cnrs.unistra.fr):

• CV
• Letter of motivation
• Names and contact details of three references